In the interest of our present and future patients we have expanded the scope of tests with pre-implantation genetic diagnostics (PGD/PGS).
IVITA clinic now has the most advanced laboratory equipped with the latest generation tools using NGS technology which is operated by specialized staff to guarantee successful and reliable results.The application of NGS allows to obtain reliability levels of approximately 99,999%.
gives 80% of certainty
What is PGD/PGS?Preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS) (preimplantation diagnostics) are diagnostic tests applied in in-vitro procedure which enable genetic examination of embryos..
The application of IVF-PGD/PGS improves the effectiveness of infertility treatment through identification of embryos which are not hereditary degenerated. It is dedicated for child- seeking couples who are at risk of genetic defects in their offspring.
For couples affected with a recognized mutation point causing specific genetic disease, it is of high importance to be able to detect such an embryo defect with the use of PGD/PGS technique.
Percentage of embryo implantation after IVF-PGD/PGS (turquoise) and IVF with embryonic morphology assessment (gray).
When and for whom?
The latest diagnostic method eliminates the risk of birth with serious incurable diseases such as Down, Turner, Patau, Edwards or Klinefelter syndrome.
Morphologically correct embryos may also have genetic defects
(Merzanidou ed., 2013).
The occurrence of chromosomal abnormalities in embryos obtained in vitro increases with the age of the mother
(Vanneste ed. 2009).
Keeping in mind the above facts, it is necessary to consider implementation of PGD technique. The indications to perform PGD comprise:
- Previous failures of IVF
- Delivering a baby with genetic defect
- Women aged over 37 years old
- Unsuccesful embryo implantation
- Recurrent miscarriage history
- Extremely reduced sperm parameters
- Recognized affection by genetic diseases of couples (or family members) trying to have a baby.
The clinic is also involved in research under the research grant funded by the National Research and Development Centerwhich is the executive agency for the Minister of Science and Higher Education.
We are the first in Poland to start a three-year research on the development of a non-invasive preimplantation method of embryo diagnosis. The method is groundbreaking, extremely detailed and accurate.A single test enables to obtain information about all chromosomes and/or the presence of genetic mutation which cause genetic diseases. The project is carried out in cooperation with a team from the University of Life Sciences led by Prof. Dorota Cieślak.
IVITA team members are a part of the elite European Society of Human Reproduction and Embryology (ESHRE) whose primary aim is to establish guidelines for doctors and laboratories in proper execution of preimplantation genetic diagnostics and collect data on the performed PGD/PGS cycles, pregnancies and childbirths. Such data is reported annually by the affiliated IVF clinics.
The application of PGD/PGS in assisted reproduction techniques is highly supported by the European Society of Human Reproduction and Embryology, the member of which was awarded the Nobel Prize in medicine, prof. Robert Edwards, the creator of in vitro fertilization.
Thanks to PGD/PGS, the effectiveness of in vitro procedure increases to 80%
Preimplantation genetic diagnostics cycles
(almost 3.000 in Spain).
Approximate performance of standard in vitro
Według ostatniego raportu opublikowanego przez ESHRE w Europie (dane z 2011 r.):
effectiveness of in vitro with the use of PGD/PGS
According to the latest report published by ESHRE in Europe (data from 2011)
Benefits of NGS method
Next generation sequencingOne of the most recent achievements in human genome analysis is Next Generation Sequencing – NGS).
Contrary to other molecular techniques, NGS is characterized by a very high resolution with the option to select methodology for a particular analysis – from detecting genomic mutation (eg. aneuploidy) to single gene mutations. Additionally, the analysis accuracy increases by a few dozen of percent in comparison to aCGH, FISH or PCR with significantly lower probability of falsely positive results.
Resolution the option to select methodology for a particular analysis
pod kątem konkretnej analizy
Resolution significantly lower probability of falsely positive results.